Nomograms predict survival outcome of klatskin tumors. A, longitudinal view of the common hepatic duct shows a tapered segment arrow consistent with tumor stricture. The current understanding of these tumors is limited to a small number of case reports or case series. Data on klatskin tumors between 2004 and 20 was extracted from the surveillance, epidemiology.
While there is no official known cause for klatskin tumors in the bile duct, there are some risk factors that have been associated with a small percentage of those diagnosed because they are known to cause biliary inflammation and may be related to klatskin tumor formation. Preoperative biliary drainage increases infectious complications after hepatectomy for proximal bile duct tumor obstruction. Typically, these tumors are small, poorly differentiated, exhibit aggressive biologic behavior, and tend to obstruct the intrahepatic bile ducts. A klatskin tumor or hilar cholangiocarcinoma is a cholangiocarcinoma cancer of the biliary tree occurring at the confluence of the right and left hepatic bile ducts. Hilar cholangiocarcinoma klatskin tumor request pdf. Igg4related sclerosing cholangitis mimicking hilar. Tumor involving the confluence of the right and left hepatic ducts is known as klatskin tumor. Klatskin tumor article about klatskin tumor by the free. After iv contrast magnevist enhancement seen in mass. The study group included hilar cholangiocarcinoma klatskin tumor in 26 patients, icteric hepatocellular carcinoma in four patients, gallbladder carcinoma in five patients, and metastasis from. Klatskin tumors are are a type of cholangiocarcinoma that begins in an area called the hilum, where the left and right bile ducts join and leave the liver. Another classification groups biliary tract cancers as intrahepatic, perihilar and distal extrahepatic. Kat not real name is a 64yearold indonesian lady from aceh.
Slightly longer survival was recorded when chemotherapy was added and also after endoscopic placement of metallic stents. Preoperative evaluation of resectability of klatskin tumor. All types of cancerous growth in the biliary duct are termed as cholangiocarcinoma. Klatskin tumor synonyms, klatskin tumor pronunciation, klatskin tumor translation, english dictionary definition of klatskin tumor. New, more aggressive surgical strategies have significantly changed treatment policy of patients with klatskin tumours. We offer a widget that you can add to your website to let users look up cancerrelated terms. A very limited number of patients with klatskin tumors are suitable for liver transplantation lt following a strict protocol with neoadjuvant. My doctor told me that radiation nor chemo affects this klatskin tumor, its so rare. But, since tumor markers can be caused by other conditions, this test isn. Klatskin tumor genetic and rare diseases information center. From my understanding, i thought that because of the strategic location of the klatskin tumor, it can cause obstruction and hence an earlier presentation by the patient with jaundice and thus these tmors can be resected with a much more reasonable and better prognosis compared to most cholangiocarcinomas. The disease was named after gerald klatskin, who in 1965 described 15 cases and found some characteristics for this type of cholangiocarcinoma.
Diagnosing klatskin cancer can be hard, and you may need to have some tests done including. This neoplasia, which originates in the epithelium of the biliary ducts, or cholangiocarcinoma cc, represents 10% of hepatobiliary tumours and 2% of malignant tumours. Discover everything scribd has to offer, including books and audiobooks from major publishers. The anatomy of the biliary ducts at the hepatic duct confluence ultimately determines whether tumorfree ductal. Klatskin tumor genetic and rare diseases information. Tumors that arise from the bifurcation of the common hepatic duct were described in 1965 by gerald klatskin, hence termed as klatskins tumor. Extent of liver resection for hilar cholangiocarcinoma klatskin. In 1965 he described the unique features of cholangiocarcinoma at the bifurcation of the main intrahepatic bile ducts, which came to be called the klatskin tumor. Endoscopic palliative therapy allowed a faster community reintegration, but with variable evolution. Mar 27, 2005 hi jackie, after several echographic tests and ctscans there was still nothing visualized. Colangiocarcinoma caso clinico medicina especialidades. Klatskin tumor definition of klatskin tumor by the free.
Click on the link to view a sample search on this topic. The objective of our study was to evaluate prospectively the preoperative use of 16mdct angiography and cholangiography in determining the resectability of klatskin tumors. This presentation will focus on new approaches for surgical treatment of klatskin tumours and its impact on the criteria used for resectability of this difficult tumour. Igg4related sclerosing cholangitis mimicking hilar cholangiocarcinoma klatskin tumor. Klatskin tumor is a type of cancerous growth develops at the junction between right and left biliary duct from where main bile duct is formed. Survival and quality of life of cholangiocarcinoma patients. The nomogram was based on 317 eligible klatskin tumor. Tumor free margins represent the most important prognostic parameter. Symptoms usually dont present until advanced stages of disease, when jaundice is the most common feature. Did your doctor that the margins were clear and what did they say was causing your fever and chills. Nomograms predict survival outcome of klatskin tumors patients.
Oct, 2016 access to this database is free of charge. A klatskin tumor or hilar cholangiocarcinoma is a cholangiocarcinoma occurring at the. It was his dream to create a histological atlas of diseases of the liver, an ambition brought to fruition in 1993 by harold conn, his first fellow and longtime collaborator at yale. With klatskin tumors, the cancerous cells may release certain chemicals known as tumor markers that can be detected using blood tests.
A solid mass seen in junction of the right and left hepatic ducts. I have two children, a daughter who is 37 and a son who is 34. Feb 08, 2018 the objective of this study was to investigate the incidence, demographics, tumor characteristics, treatment, and survival of patients with hilar cholangiocarcinoma. Feb 18, 2020 the median os in the klatskin tumor group was 5 months compared with 26 and 68 months in the icca and hcc groups, respectively. The proximal extent of tumor into the intrahepatic biliary tree largely determines. Klatskin tumor, or hilar cca involving the bifurcation of the hepatic duct, accounts for approximately 60 % of all bile duct cancers and is the second most common primary malignant hepatobiliary neoplasm. While there is no official known cause for klatskin tumors in the bile duct, there are some risk factors that have been associated with a small percentage of those diagnosed because they are known to cause biliary inflammation and may be related to klatskin tumor formation primary sclerosing cholangitis. Comprometimento linfonodal perihilar hepatico e do retroperitonio no estadiamento.
Pdf demographics, tumor characteristics, treatment, and. Ca staging manual, there is now a new distinct staging system for. After a ercp they came to the conclusion that it has to be a klatskin tumor due to the location of the tissue the upper bile duct and part of the liver. There is marked dilatation of the intrahepatic ducts. It is the most common type of cholangiocarcinoma, accounting for more than half of all cases. During surgery they dicovered the liver was infected by 80%. Her problems started about three weeks ago when she felt dizzy and had abdominal pain.
Guidelines for the diagnosis and management of intrahepatic. Apr 07, 2020 a klatskin tumor is a tumor which forms in the upper region of the bile duct, where the left and right bile ducts meet. The median cancerspecific survival in the klatskin tumor group was 10 months compared with 34 months in the icca group p oct, 2016 klatskin tumors are are a type of cholangiocarcinoma that begins in an area called the hilum, where the left and right bile ducts join and leave the liver. Klatskin tumor patients than in patients with other types of tumors. Klatskin tumors are rare, malignant tumors of the biliary system with a poor prognosis for patient survival.
The nci dictionary of cancer terms features 8,547 terms related to cancer and medicine. Bile duct cancer of the upper part of the bile duct is also called klatskins tumor. Apr 20, 2020 ferrero a, lo tesoriere r, vigano l, caggiano l, sgotto e, capussotti l. Prognosis for the patient depends on the size of the tumor at the time of diagnosis, whether the left and right bile ducts are also involved, and the patients general physical condition. Demographics, tumor characteristics, treatment, and survival. B, transverse image at the biliary confluence reveals an echogenic mass arrow at the bifurcation and dilated bile ducts in both lobes. Hilar cholangiocarcinoma hc was first described by altemeier and klatskin. Demographics, tumor characteristics, treatment, and survival of patients with klatskin tumors.
Perihilar bile duct tumors can be further classified as type 1 through type 4, depending on the site of involvement of the ducts. Pdf hiliar cholangiocarcinoma is the most common type of cholangiocarcinoma, an represent around 10% of all hepatobiliary tumors. A localonly recurrence after surgery for klatskin tumors is. Pdf intestinal biliary bypass in klatskins tumor treatment. However, this is not free of complications, and those associated with ercp with. Among this almost 60% to 70 % biliary duct cancer is klatskin tumor 1,2. Objective klatskin tumors are rare, malignant tumors of the biliary system with a poor prognosis for patient survival. Ccch16 originados na bifurcacao do ducto hepatico prin cipal9, cuja localizacao e extrahepatica. Methods a population cohort study was conducted in patients selected from the surveillance, epidemiology, and end.
Metachronous ampulla of vater carcinoma after curativeintent. Typically, these tumors are small, poorly differentiated, exhibit aggressive biologic behavior, and tend. Klatskin tumor is a term that was traditionally given to a hilar cholangiocarcinoma, occurring at the bifurcation of the common hepatic duct. Hilar resections as least radical resective procedure will generate rates of formally curative resections of less than 50%. Pubmed is a searchable database of medical literature and lists journal articles that discuss klatskin tumor. Furthermore, the median disease free survival time after curativeintent surgery for klatskin tumor was reported between 14 months and 17 months 3,4,8. Definition of klatskin tumor nci dictionary of cancer terms.